Top 20 Interview Questions & Answers for Oncology RN Roles – 2025

Are you preparing for an interview for an oncology registered nurse (RN) role? This guide provides a list of essential questions and answers that will help you showcase your knowledge, skills, and experience in caring for patients with cancer. Whether you’re a new graduate or an experienced RN, these questions cover all key areas of the job.

Behavioral Questions

• 1. Tell me about a time when you had to provide emotional support to a patient with a terminal cancer diagnosis.
  Answer: In my previous role as an oncology RN, I had a patient who was diagnosed with late-stage lung cancer. I could see the fear and sadness in their eyes during our initial conversation. I took the time to sit with them, listen to their concerns, and provide reassurance and support. Throughout their treatment, I made it a point to always check in with them and provide a calming presence during their appointments. It was humbling to see the patient open up and trust me to be their support system during such a difficult time.
• 2. How do you handle difficult or aggressive patients in an oncology setting?
  Answer: Communication and empathy are key in handling difficult or aggressive patients in an oncology setting. I always make an effort to understand where the patient is coming from and address their concerns with compassion. I also utilize de-escalation techniques, such as maintaining a calm tone and acknowledging their feelings. I have found that listening to the patient and reassuring them that I am there to help them can diffuse most situations.
• 3. Describe a time when you had to advocate for a patient’s needs and ensure they received appropriate care.
  Answer: During my time in an oncology unit, I had a patient who was experiencing severe reactions to their chemotherapy treatment. The physician did not want to alter the medication, but after closely monitoring the patient and consulting with the interdisciplinary team, I presented a strong case for changing the treatment plan. I advocated for the patient's needs and fought for them to receive the best possible care. In the end, the patient's condition improved, and they were grateful for my determination.
• 4. How do you handle difficult or emotional conversations with patients and their families?
  Answer: Difficult or emotional conversations with patients and their families are a common occurrence in an oncology setting. My approach is to be honest, compassionate, and empathetic. I take the time to listen to their concerns, validate their feelings, and provide guidance and support. I also ensure that I am fully informed and prepared to address any questions or uncertainties they may have.
• 5. Tell me about a time when you had to collaborate with other healthcare professionals to develop a patient care plan.
  Answer: In a recent case, I had a patient who was receiving treatment for breast cancer. As an RN, I worked closely with the patient's oncologist, radiation oncologist, and other members of the healthcare team to develop a comprehensive care plan. We discussed the patient's progress, side effects, and any necessary changes to the treatment plan. Through open communication and collaboration, we were able to provide the patient with the best possible care and achieve a positive outcome.

Situational Questions

• 6. How would you handle a situation where a patient refuses to continue with their treatment plan?
  Answer: If a patient refused to continue with their treatment plan, I would first try to understand the reasons for their decision. It could be due to fear, financial constraints, or other personal factors. I would then provide them with all the necessary information about their condition, the potential consequences of not following the treatment plan, and alternative options. I would also involve their family and other healthcare professionals in the decision-making process to ensure that the patient receives the best care possible.
• 7. What would you do if a patient experienced a medical emergency during treatment?
  Answer: In the event of a medical emergency during treatment, I would first ensure the safety and well-being of the patient. I would then follow the proper protocol, such as calling for assistance and administering emergency care. I have experience in basic life support and Advanced Cardiovascular Life Support (ACLS) and would use my training to stabilize the patient until the emergency team arrives. After the situation is under control, I would document the incident and follow up with the patient's physician.
• 8. How would you handle a situation where a patient does not speak the same language as you?
  Answer: Effective communication is crucial in providing quality care to patients, regardless of their language. If faced with a patient who does not speak the same language, I would first try to identify a family member or friend who could assist with interpretation. If that is not possible, I would use various resources, such as a medical interpreter or translation software, to communicate with the patient and ensure they understand their treatment plan and any important instructions.
• 9. What steps would you take to ensure patient safety in an oncology unit?
  Answer: Patient safety is a top priority in an oncology unit. To ensure patient safety, I would follow all necessary safety protocols, such as proper hand hygiene, medication administration, and infection control measures. I would also pay close attention to any changes in the patient's condition and report them to the physician immediately. Proper communication and patient education about their treatment plan and any potential side effects would also be essential to maintaining patient safety.
• 10. How do you handle conflicting priorities in a fast-paced oncology environment?
  Answer: As an oncology RN, I am used to working in a fast-paced environment with multiple priorities. To handle conflicting priorities, I would first assess the situation and determine which tasks are most urgent and important. I would then prioritize my workload and communicate with my team to ensure that we are all on the same page. If necessary, I would delegate tasks and manage my time effectively to ensure that all priorities are addressed in a timely manner.

Technical Knowledge & Experience

• 11. Describe your experience with administering chemotherapy and managing its side effects.
  Answer: In my current role as an oncology RN, I have experience with administering chemotherapy and monitoring patients for potential side effects. I am familiar with the different types of chemotherapy and their potential side effects. I also closely monitor my patients during treatment and educate them about self-care and how to manage any side effects at home. I have also received specific training and certifications in administering chemotherapy.
• 12. How do you stay current with advancements and changes in oncology treatments and protocols?
  Answer: As a dedicated and lifelong learner, I am committed to staying current with advancements and changes in oncology treatments and protocols. I regularly attend conferences and seminars, read research articles, and participate in discussions with my colleagues. I also take advantage of training opportunities and seek feedback from my patients and other healthcare professionals to continuously improve my knowledge and skills.
• 13. How do you maintain accurate patient records and documentation in an oncology setting?
  Answer: Accurate and thorough documentation is imperative in an oncology setting to ensure patient safety and quality of care. I follow established protocols and guidelines for documentation and use electronic medical records to maintain accuracy and completeness. I also regularly review and update patient information and communicate any changes to the appropriate healthcare professionals. I understand the importance of confidentiality and ensure that all patient records are kept secure.
• 14. Describe your experience with administering blood transfusions.
  Answer: I have experience with administering blood transfusions in an oncology setting. I am familiar with the process and have received specific training and certifications in performing blood transfusions. I closely monitor the patient's vital signs and watch for any potential reactions. I also educate the patient about the procedure and provide post-transfusion care and follow-up.
• 15. How do you handle medication errors in an oncology setting?
  Answer: Although rare, medication errors can occur in any healthcare setting. If a medication error does occur, I take immediate action by notifying the physician, documenting the error, and following the facility's protocol for reporting and preventing any potential harm to the patient. I also use the incident as a learning opportunity and make any necessary changes to my practice to prevent future errors.

Cultural Fit Questions

• 16. What values do you think are important for an oncology RN?
  Answer: I believe that empathy, compassion, and resilience are crucial values for an oncology RN. These values allow me to connect with patients, understand their needs, and provide the best care possible during such a difficult time. I am also committed to continuous learning and teamwork, as these values are necessary for providing quality care and improving patient outcomes.
• 17. How do you prioritize maintaining patient dignity and respect in an oncology setting?
  Answer: Maintaining patient dignity and respect is essential in any healthcare setting, especially in oncology. I prioritize this by communicating clearly and honestly with my patients, listening to their concerns, and involving them in their care as much as possible. I also take the time to get to know each patient as an individual and provide care that aligns with their cultural beliefs and preferences.
• 18. How do you handle stress and prevent burnout in a demanding oncology role?
  Answer: Burnout is a common issue in demanding healthcare roles, especially in oncology. To prevent burnout, I take care of myself physically, mentally, and emotionally by engaging in activities that bring me joy and relaxation outside of work. I also openly communicate with my team and seek support when needed. Additionally, I reflect on the meaningful impact of my work and remind myself of the importance of self-care in providing quality care to my patients.
• 19. How do you address cultural and religious differences when providing care to patients?
  Answer: Cultural and religious differences can significantly impact a patient's care. I make a conscious effort to understand and respect these differences in my practice. I take the time to ask the patient about their cultural and religious beliefs and consider these when developing their care plan. If necessary, I will involve spiritual or cultural leaders to assist with patient care. I also educate myself and stay informed about different cultures and religions to provide culturally sensitive care.
• 20. What motivated you to become an oncology RN?
  Answer: My motivation to become an oncology RN stems from a personal experience with a family member who battled cancer. Witnessing the compassion and care provided by the oncology RNs during that difficult time inspired me to pursue a career in oncology nursing. I am passionate about helping and supporting patients with cancer and their families during their journey, and it brings me joy to make a positive difference in their lives.